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OurPrivacy Noticeexplains more about how we use your data, and your rights. You can unsubscribe at any time.Thank you for subscribingWe have more newslettersShow meSee ourprivacy noticeMutations in the Covid virus are more likely to happen with chronic infections, say University of Cambridge researchers.In cases where a patient has the virus for an extended period of time, the virus has multiple opportunities to evolve, said the scientists.In their report, the Cambridge researchers wrote that they observed the virus mutating in the case of an immuno compromised patient in his 70s being treated at Addenbrooke’s Hospital.In particular, they saw the emergence of a key mutation also seen in the variant first seen in Kent, though there is no suggestion that the variant originated from this patient.Using a synthetic version of the virus spike protein created in the lab, the team found that specific changes to its genetic code the mutation seen in the Kent variant made the virus twice as infectious on cells as the more common strain.The spike proteins on the surface of the virus attach themselves to the receptors on the surface of the host’s cells, which is how it spreads throughout the body.You can see how many cases there are in your local area in the widget below:Most of the current vaccines in use or being trialled target the spike protein and there is concern that mutations may affect the efficacy of these vaccines.UK researchers within the Cambridge led COVID 19 Genomics UK Consortium have watched the variant mutate in an individual.Though the variant has been detected multiple times, until now scientists have not observed them emerge in an individual.The patient had previously been diagnosed with marginal B cell lymphoma and had recently received chemotherapy, meaning that his immune system was seriously compromised.After admission, the patient was provided with a number of treatments, including the antiviral drug remdesivir and convalescent plasma that is, plasma containing antibodies from a recovered patient.Read MoreCambridgeshire postcodes that have seen biggest fall in infection ratesDespite his condition initially stabilising, he later began to deteriorate. He was admitted to the intensive care unit and received further treatment, but later died.During the patient’s stay, 23 viral samples were available for analysis, the majority from his nose and throat.Between days 66 and 82, following the first two administrations of plasma, the team saw a dramatic shift in the virus population, with the mutated virus becoming dominant.Although this variant initially appeared to die away, it re emerged again when the third course of remdesivir and convalescent plasma therapy were administered..